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Surescripts
healthcare professionals and organizations used Clinical Direct Messaging in 20251
prescription changes made using CancelRx in 20252
of all E-Prescribing transactions augmented by Sig IQ in 20253
Deliver a seamless pharmacy experience—today and as care evolves
For many patients, the pharmacy is the most accessible place to get care, and pharmacists are well positioned to help them manage their medications and stay on track. That starts with everyday work that flows smoothly. When prescriptions or benefit information arrive unclear or incomplete, pharmacy teams are forced to step out of their workflow to call or fax prescribers and benefit plans. Without connections to clinical information and the wider care team, pharmacists can also be left out of care coordination. Having access to trusted data and resilient connectivity changes that—helping keep every fill on track and giving pharmacists the insights and connections they need to play an even larger role in patient care.
Missing or messy prescription data slowing pharmacy workflows
Limited in-workflow connections to clinical information & other care providers
Growing threats to operations—including cyberattacks & adverse weather events
Quality safeguards that deliver complete & accurate prescriptions
Seamless connectivity between pharmacies, prescribers & payers
Built-in data protection and redundancy, backed by 99.998% average network uptime4
Safe, clear prescriptions with less need for manual outreach
Easier, in-workflow collaboration across healthcare
Reliable operations that keep prescriptions moving, even during disruptions
Seamless prescription transfers are saving time for pharmacists and prescribers—while helping patients get medications without delay.
Do more for patients with trusted, connected pharmacy workflows
Filling prescriptions is only the beginning. Pharmacies need clean, complete prescriptions, a network they can count on and easier ways to collaborate across the care journey. With a single, neutral connection to prescribers, payers and health systems nationwide, you can fill with confidence, access richer patient insights within existing workflows and help patients get the medications they need.
Fill with confidence
Help pharmacists confidently fill prescriptions and easily communicate with prescribers.
Expand interoperability
Bring pharmacists more patient insights and better communication channels.
Connect with our team to explore how we can help you fill with confidence, collaborate with ease and keep patient care on track.
Real-world results
Surescripts named to RxInsider’s Pharmacy500 list: Pharmacy500 recognizes organizations that meaningfully support dispensing pharmacies across the U.S. Honorees demonstrate a national presence, sustained commitment to pharmacies and active engagement with the pharmacy community.
“In order for us to drive a scalable solution, it's ‘all boats rise’ when we're able to do it for the industry versus if us at Walgreens just do it individually. Hence, why it's important for us to have partners like Surescripts.”
Expertise that supports your goals
We’ll work with you every step of the way to ensure a smooth solution implementation.
We’ll partner with you to develop powerful materials that influence resale and adoption.
We’re optimizing performance to improve prescription accuracy industrywide.
Keep pace with healthcare innovation
Find out more about how we help pharmacies
What challenges do pharmacies face that Surescripts can help address?
Pharmacists often expend valuable time tracking down patient information through phone calls and faxes, which can slow prescription fulfillment, contribute to patient nonadherence and limit capacity to provide clinical care. Surescripts helps pharmacists spend more time assisting patients and less time chasing information.
How does Surescripts support pharmacy workflows?
Surescripts provides connectivity and trusted health intelligence that helps pharmacies access coverage information, communicate securely with prescribers and manage prescriptions efficiently within existing workflows.
How does Surescripts improve the prescribing process for pharmacies?
Surescripts supports clearer, safer and more efficient prescription management by standardizing e-prescribing transactions and reducing the need for manual follow-up with prescribers.
How does Surescripts help reduce administrative interactions like calls and faxes?
Secure electronic communication tools and standardized e-prescribing transactions help replace manual outreach with prescribers and payers, enabling pharmacists to focus more on patient care.
How does Surescripts support pharmacy interoperability?
Pharmacists need complete patient information and clear communication channels with other care team members in order to support coordinated care and reduce errors. With connections to 2.32 million healthcare professionals and provider organizations, Surescripts brings pharmacies a comprehensive and connected view of patient care.
- Surescripts, “2025 Annual Impact Report,” p. 22.
- Surescripts, “2025 Annual Impact Report,” p. 11.
- Surescripts, “2025 Annual Impact Report,” p. 7.
- Surescripts, "2025 Annual Impact Report," p. 22.