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Surescripts
Our Impact
Advancing healthcare across the country
Transforming healthcare with trusted intelligence
We’re putting interoperability to work and empowering healthcare organizations across the country with the intelligence they need to optimize outcomes and operate more efficiently. Together, we are making progress toward better, safer, more cost-effective care.
Increasing patient safety
300
%Quality Index Score improvement since 20161
84.4
%of prescribers enabled to e-prescribe controlled substances2
2.7
ximprovement in successfully canceling discontinued medications with CancelRx3
Lowering costs
77
average savings per prescription with Real-Time Prescription Benefit4
5.07 billion
care events informed by Eligibility data in 20255
40
%lower out-of-pocket cost for high-cost drug classes6
Ensuring quality care
5.97 billion
clinical document links delivered in 20257
86
%of medication history responses augmented in 20248
376.7 million
HIPAA-compliant Clinical Direct Messages exchanged in 20259
Real-world results
Tracking the impact of health intelligence sharing across the United States
In 2025, the Network Alliance exchanged more health intelligence than ever before.
2.32 million
+1% yoy
99.998
%network uptime
insured Americans in our Master Patient Index
30.5 billion
+12.3% yoy
39.16
millisecondsto retrieve an accurate patient match
5.7
billionlinks to clinical document sources exchanged
Tracking trends & uncovering opportunities
Tap into our reports and data briefs to see how the Surescripts Network Alliance is moving the needle on some of the biggest healthcare challenges.
Honoring leaders in data accuracy and performance
The Surescripts White Coat Award celebrates leaders across the Network Alliance who are advancing prescription accuracy and performance.
Highest Performance
Recognizing the best overall accuracy score as measured by our data analysis engine that monitors e-prescription accuracy and pinpoints areas for improvement.
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Innovation
Showcasing organizations making innovative strides toward performance optimization across the healthcare continuum—ultimately helping provide quality care in a timely manner.
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RxChange Champion
Highlighting organizations successfully advancing the RxChange transaction, which lets pharmacies communicate with prescribers to resolve prescription concerns within their electronic workflow.
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Keep pace with healthcare innovation
- Surescripts' Quality Index Score measures the effective use of 16 key elements of electronic prescriptions, such as drug description, days supply, and potency unit code. Surescripts, “2023 National Progress Report,” p. 3.
- Surescripts, “2025 Annual Impact Report,” March 2026, p.10.
- Taylor L. Watterson et al., “CancelRx Implementation: Observed Changes to Medication Discontinuation Workflows Over Time,” Exploratory Research in Clinical and Social Pharmacy, January 25, 2022. Pharmacy cancellation rate improved from 34% to 93% after implementation.
- Surescripts, “2025 Annual Impact Report,” p.14.
- Surescripts, “2025 Annual Impact Report,” p.14.
- Sunita M. Desai et al., “Effects of Real-Time Prescription Benefit Recommendations on Patient Out-of-Pocket Costs,” JAMA Internal Medicine 182 (11): September 12, 2022.Surescripts, “2022 National Progress Report,” March 2023.
- Surescripts, “2025 Annual Impact Report,” p.22.
- Surescripts, “2024 Annual Impact Report,” p.20.
- Surescripts, “2025 Annual Impact Report,” p.22.