Since 2001, we've been building an industrial-strength health information network designed to increase safety, lower costs and improve quality.



Convening the Industry to Deliver Actionable Intelligence

Surescripts transmits 13.7 billion transactions annually, including nearly 4.8 million e-prescriptions daily. But scale alone isn’t what makes us different. It’s the unprecedented participation we’ve achieved across the healthcare marketplace, including healthcare providers, pharmacies, health plans, PBMs and technology partners. We call it the Surescripts Network Alliance.

The Network Alliance includes virtually all electronic health records (EHRs), pharmacy benefit managers (PBMs), pharmacies and clinicians, plus an increasing number of health plans, long-term care settings and specialty pharmacy organizations.

In addition to our solutions, participants have three core elements unique to the Surescripts Network Alliance.

Intelligence Enablers

Our Intelligence Enablers include a provider directory of 1.47 million, a master patient index of 233 million patients and revolutionary workflow, administration and analytic tools.

Trust, Quality & Reliability

Our Trust, Quality & Reliability pillars rely on the highest security levels, high availability operations, and protection of prescriber choice of therapy and patient choice of pharmacy. Plus, Surescripts Sentinel™ analyzes transactions to identify opportunities to improve patient safety, quality and cost.


Our Governance best practices encourage innovation and competition, and include network formation processes, adoption tiers, development partnerships and participant commitments.

We work shoulder to shoulder with our customers to:

Enhance Prescribing

Collectively enabling safer and more affordable prescriptions.


E-Prescribing gives healthcare professionals in all care settings safer and more efficient electronic prescription management.

Benefit Optimization delivers real-time, patient-specific benefit, price and therapeutic alternative information to the point of care.

Prior Authorization provides seamless, real-time, EHR-integrated electronic prior authorization at the point of care.

Specialty Medications can be prescribed and fulfilled more quickly and easily with tools that simplify the prescribing process.

Inform Care Decisions

Arming Healthcare Professionals with Actionable Patient Intelligence.


Clinical Direct Messaging offers secure delivery of clinical communications and data for improved care coordination and workflow efficiency.

Medication History data that is aggregated and delivered to the point of care gives a more complete picture of patients’ health history.

Clinical History information that is patient-specific and accessible regardless of geography, care provider or EHR improves care quality.

Insights & Alerts provide data at the point of care to address adherence issues and improve patient outcomes while reducing costs.

Advance Healthcare

Convening, Informing and Advocating for the Healthcare Industry.


Our history, scale and experience allow us to detect emerging challenges, their potential impact and how to navigate them across markets.

Intelligence in Action

Surescripts Helps Customers Reach Their Highest Potential

We don’t exist to merely move data around—we’re here to serve and share the wealth of information that makes healthcare better for all.

Increasing Patient Safety

We processed 3.8 million CancelRx transactions in 2017 to prevent discontinued medications from being dispensed.

Lowering Costs

E-Prescribing has been shown to reduce costs by $140–$240 billion over ten years.*

Ensuring Quality Care

Medication adherence improves by 20% when actionable patient intelligence is delivered within the EHR.**

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*Study: E-Prescribing Shown to Improve Outcomes and Save Healthcare System Billions of Dollars, February 1, 2012